Thank you, though I am more afraid this will make my positive symptoms worse. I really have no negative symptoms of schizophrenia, which is why I am schizoaffective and not schizophrenic. Glycine seems to activate the glutamate receptors[1] and sarcosine is a by product of glycine and has also been shown to increase mania in patients[2].

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10740625/

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC4356443/

What is interesting is that high levels of B6 seemed to help me in the past and it is a cofactor for SHMT1[1] which balances serine and glycine in the folate cycle.

[1] https://www.uniprot.org/uniprotkb/P34896/entry

On SHMT1 and mood: https://www.sciencedirect.com/science/article/pii/S075333222...