A brief history of oral peptides
48 points
1 day ago
| 6 comments
| seangeiger.substack.com
| HN
celltalk
2 hours ago
[-]
It’s a great read but is this really the history of oral peptides?
reply
abainbridge
1 hour ago
[-]
Yep, I think it is. The point is there's almost no history of oral peptides, other than stomachs destroying them.

FTA: "So to summarize the state of the art in oral peptide delivery: there are exactly two FDA-approved products that use permeation enhancers to get peptides into your bloodstream through your GI tract. Both achieve sub-1% bioavailability. Both required over a decade of development, thousands of clinical trial participants, and hundreds of millions of dollars."

reply
badc0ffee
46 minutes ago
[-]
Informative article but I feel like it could have benefited from a paragraph about what Hims is. I had never heard of them before.
reply
Kaminsk13
1 day ago
[-]
I'm not sure why the hims investors ever thought that this was legal
reply
InsideOutSanta
2 hours ago
[-]
They probably didn't, they just took the bet that this was one of the crimes that are currently legal, like crypto scams, environmental crimes, bribery, and tay evasion for the rich.
reply
badrequest
1 hour ago
[-]
Some of the most profitable ventures this century have been objectively illegal, but when you know you won't go to prison for violating the law, why would you care to follow it?
reply
kps
2 hours ago
[-]
The charitable assumption is that investors weren't aware it was a problem.
reply
Boot2Root
23 hours ago
[-]
Appreciate the perspective on the risk of dubious formulations. Consequences are far more than cosmetic.
reply
ftchd
2 hours ago
[-]
thanks, needed this for a mogging session later
reply
ydai0531
1 day ago
[-]
great read!
reply