Right and if that is such a good thing why are those macrophages not always on alert. I smell longterm cancer or similar.
Or simply autoimmune reactions which can be devastating.
>There may also be consequences to dialling up the immune system beyond its normal state – raising questions of immune disorders.
> Jonathan Ball, professor of molecular virology at the Liverpool School of Tropical Medicine, said the work was undeniably "exciting" but cautioned "we have to ensure that keeping the body on 'high alert' doesn't lead to friendly fire, where a hyper-ready immune system accidentally triggers unwelcome side effects".
> The research team in the US does not think the immune system should be permanently dialled up and think such a vaccine should be used to compliment rather than replace current vaccines.
The body is like legacy spaghetti code written by hundreds of teams of outsourced engineers. It mostly works. Just never remove any commented out lines or it may break.
there's probably a reason evolution didnt put the immune system on permanent "amber alert" as they call it in the article
Amber alert means something different than the author thinks ...
I personally look forward to every innovation that potentially improves our baseline.
It would just be temporary, but there is likely trade offs.
Until we find out why nature made it so some of us kill ourselves maybe we shouldn't fuck with it? Remember Chesterton's Fence.
"Sorry son, you can't get these glasses. It's for the betterment of humanity."
Remember that cephalopod brains are donut shaped and their digestive tracts go right through the middle and if they eat something too big they'll have an anyeurism. Pandas and koalas evolved special diets that serve no evolutionary purpose and both would be extinct if humans didn't find them cute. Sloths have to climb down from trees to take a shit. Female hyenas give birth through a pseudopenis that often ruptures and kils them. Horses can't vomit and if they swallow something toxic, their stomach ruptures. Also their hooves and ankles are extremely weak and not well designed to support their weight. Numerous species like the fiddler crab and peacock have evolved sexual displays that are actively harmful to their survival.
And as for humans, our spines are not well adapted for walking upright, our retinas are wired backwards, and we still have a useless appendix and wisdom teeth. The recurrent laryngeal nerve has an unnecessarily long and complex route branching off the vagus and travelling around the aorta before running back up to the larynx.
Evolution is not smart. Evolution isn't even stupid. It isn't trying to keep you alive and it isn't even capable of caring if you die. Yes we should absolutely fuck with it, because we don't want to live in a world where we still die of sepsis and parasites and plagues because "we don't want to mess with evolution."
Koalas biggest problem is us? Like they seem perfectly adapted to their niche. Eat lots of leaves that nobody else is adapted to use as food, and once a year, run very fast to outpace the bushfire that your principle food source needs to reproduce.
In my defense, domestication is still technically an evolutionary process.