Something I should have mentioned is that we could have avoided the new APIs if only there was space in the ffi_cif to stash a plan pointer. And I didn't want to break ABIs for this.
Notably, the COM bytecode covers not only procedure-level argument-passing, but data structure transformations themselves. It's a nice setup.
Keep in mind that optimizing the call doesn't optimize the marshaling: even with an AOT-compiled FFI trampoline, if you're, say, sending a string from one place to another, you usually need to transform the string in some manner (copy it, change encoding, add/remove length prefixes, etc.) and JITing the libffi parameter passing won't help you do the string stuff any faster.
In fact, trying to AOT the connections can make your program worse, both by bloating it (causing some likely small, but still, cache pressure) and by complicating your build and deployment process.
libffi bytecode is good. I wouldn't bother with native code until I had a profile in hand showing the bytecode to be the bottleneck, and even then, I'd check it a three or four times to make sure I didn't get the profiling wrong. FFI is just seldom the problem in real-world systems.