The first early human eggs from stem cells
94 points
3 hours ago
| 8 comments
| conception.bio
| HN
londons_explore
58 minutes ago
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I am worried about the long term impact of research involving human conception, IVF, etc.

The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human.

I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation, gut bacteria passing from mother to child, selection of the 'correct' egg or sperm out of millions, or something new and un-discovered etc.

And if those effects are bypassed with artificial conception, we might end up with humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc.

The effect will be small for each generation, but after 5-10 generations of a combination of artificial and natural conception you could end up with meaningful loss of fitness - or perhaps a lack of gain of fitness that would have otherwise occurred.

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dsign
3 minutes ago
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> but after 5-10 generations of a combination of artificial and natural conception you could end up with meaningful loss of fitness

Yes, if we end up in some corner-case dystopia where evolution and natural selection continue to be in charge of fitness. But evolution and natural selection bring much suffering to the unlucky. In other words, if you go to a hospital, you'll quickly learn there's far more human suffering caused by God and Nature than by the "cruelty of man". Though common sense is never assured victory, I look forward to a world where our children live healthier and longer lives due to us properly messing with God and Nature.

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saturn8601
1 minute ago
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Very interesting...maybe this is another great filter preventing a species from becoming multi planetary or expanding beyond a type 0 civilization?
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noosphr
33 minutes ago
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>I am worried about the long term impact of research involving human conception, IVF, etc.

You'd have a rather different opinion if you had to squeeze out a water melon out of your genitals.

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dashtiarian
12 minutes ago
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Nobody HAS to do that. If people WANT to have children they should give them the best chances they can. If science proves IVF is the best, every parent must do it, if it's risk freedom has not been proved yet, no person that has other options available should do it. Chances are they would be ruining their children's life by expecting and comparing them to the best, so they can at least not give them handicap from birth. The world is now much more competetive and unfair to our children than it was in our time. My mother has told me countless times that childbirth is one of easier parts of motherhood.
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piker
2 minutes ago
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What?
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latexr
11 minutes ago
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What? IVF doesn’t mean that the human is gestated in a glass tube like some 80s sci-fi, the pregnancy and birth still have to occur, carried out by a human.
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warent
49 minutes ago
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You’re layering several hypotheticals on top of each other, which leads to progressively distant possibilities. Good on you for caring about humans though
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tskj
30 minutes ago
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I think this is decisively the wrong way to think about it. Yes, layering hypotheticals like that means that any one scenario is extremely unlikely to be the thing that gets you, but that doesn't mean the shape of the problem is wrong.

It's like arguing with someone who doesn't believe in using seat belts when driving. "Why should I put them on?" they say, and when you try to explain what might go wrong they won't listen to any explanation that isn't a hyper-concrete hypothetical. So finally you give in and say, "Well, when we get onto the highway, a truck might lose control and hit us", and their response is "I don't think that's very likely, it seems highly improbable that today we will be hit by a truck when getting on the highway".

I agree with OP that this seems like the kind of thing where the unknown unknowns are so great that the correct approach is serious caution, and that any demand to know exactly how or why it will go wrong, falls in the trap where every specific example is very unlikely to be the thing that goes wrong, but still in total there's like an 80% chance that it goes horribly wrong. I don't know if we have the terminology to talk about this kind of failure mode. "You shouldn't play God" maybe? At least you shouldn't ask for specific examples of how things could go wrong, if you're going to turn around and claim each one highly improbable.

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zigzag312
21 minutes ago
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But many of the listed hypotheticals are not dependent (on top) on others, and since there are multiple that actually increases probability of an undesirable outcome.
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Davidzheng
38 minutes ago
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But it reads to me like the thread parent's point is that there are many unknown risks which can exist? I also wonder about long term effects to the health of the genome from IVF and other forms of fertility treatment as infertility could be acting as some sort of protection mechanism of the genome. But I suppose such objections form a continuum which extends to treatment of all genetic diseases or diseases in general--all of which probably applies some evolutionary pressure towards more healthy individuals but which we as a society have to balance against wellbeing of individuals and their human rights.
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tskj
26 minutes ago
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This seems distantly impossible right now, but for this reason, I predict that any species that survives this kind of "great filter" effect of accidentally messing up their genome long term, will develop a strong taboo against fertility treatments and treatment of genetic diseases.

Like it seems horrible not to help the individual, when we have the technology to; but it's also horrible to hurt your species by selfishly propagating faulty genes. And this seems like the kind of problem cultural taboos are good at solving, and I don't really see any other mechanism by which a species can avoid this filter trap.

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londons_explore
29 minutes ago
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There is precedent for infertility being beneficial for a species in the animal kingdom. For example the vast majority of ants and bees are infertile. Yet the infertile ones still contribute meaningfully to society.

Humans could easily be successful with a similar model, and did so in the past before fertility treatments.

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close04
18 minutes ago
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If I understand your point correct it could work as easily as communism: theoretically sound but undermined by human psychology. Natural evolution is slow and gives the species time to adapt to anything. Artificial evolution by comparison is very fast. But the real issue is that humans have intelligence, individuality, and egotism. We don’t see ourselves as just part of a collective.

Societies functioned in the past while taking away some rights from its citizens (like ownership) but nothing as fundamental as only a few able to reproduce.

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Arodex
13 minutes ago
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>The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human.

I didn't have "creationism" as the top answer to a HN post in 2026, yet here we are...

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fragmede
8 minutes ago
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Anti-intellectuallism is everywhere, especially amongst the intellectuals. The latest bent of this is to ask if an AI wrote this, rather than engage with the substance of what's written.
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weregiraffe
16 minutes ago
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>The effect will be small for each generation, but after 5-10 generations of a combination of artificial and natural conception

How do you know it? Sci-fi tropes are not a good argument.

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gnabgib
3 hours ago
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Related (2021) Turning stem cells into human eggs (97 points, 102 comments) https://news.ycombinator.com/item?id=29040823
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misiek08
2 hours ago
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How hard you have to work to break scroll on web page? Nice article, but going through it was a technical nightmare.

Can we stop adding unnecessary JS to website to stop global warming by calculating AND ALTERING SCROLL?

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happymellon
1 hour ago
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Odd. It was a designers dream (and a readability nightmare) but I didn't have an issue with scroll.

Firefox on Samsung S23, not exactly a new or a powerful phone but rendered it fine.

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tskj
42 minutes ago
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Why is it a designer's dream to hijack and control my scrolling experience? The scroll they've implemented is slow to respond, and has a weirdly low capped max speed. I don't understand why that's what a designer dreams of doing to me. I like my scroll (and other computer interactions for that matter) to be responsive and fast. You know, the kind of thing that puts me in control, not the designer.

That being said, the scroll was as smooth as regular webpage scrolls. Usually these JS scrolls aren't able to avoid dropping frames or otherwise introducing judder, but this one does appear to run at a consistent and high framerate, which is technically impressive.

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sudo_cowsay
2 hours ago
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Good idea in theory but terribly impractical in practice.
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scotty79
2 hours ago
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That can't be good. Life cycle of a human egg is organized around preserving mitochondria to be as young and fresh as possible across generations. Using adult cell, even a stem cell to make an egg probably gives it mitochondrial damage that usually takes hundreds of human generations to accumulate.
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treyd
1 hour ago
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I wonder if you could coax cells from the testes back into stem cells to then re-specialize into ovarian cells.
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Schlagbohrer
1 hour ago
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Reverse Cremaster cycle?
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Protostome
1 hour ago
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Mitochondria can be translplanted/replaced. There already therapies and babies born out of these kinds of procedures
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scotty79
1 hour ago
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Can you point me to anything about mitochondrial transplants? I'd love to see bat mitochondria transplanted into other mammals. They must have really superior ones given the energy expenditures needed to support flight and their long lifespans.
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Protostome
1 hour ago
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I will let the experts continue from here :) This review is from 2020, i bet things have progressed since then

https://pmc.ncbi.nlm.nih.gov/articles/PMC7169912/

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type0
1 hour ago
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I don't, isn't this the recipe to get IRL Morbius?
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Schlagbohrer
1 hour ago
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Batboy, real at last
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Jackobrien
1 hour ago
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Really interesting point if true. Makes sense to me, and I’m sure the team is trying to solve it
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khazhoux
50 minutes ago
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Instead of just dismissing this and saying this can't possibly work, it would be better to ask: how do they get around problems of mitochondrial damage, or have they not tackled that yet?

Because it is unlikely that you just punched a hole through the plan of the several dozen people in bioengineering, life sciences, and other related fields that are at this company.

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rf15
1 hour ago
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genuinely curious: how does any life still exist if this holds true?
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jmcgough
6 minutes ago
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I think they're arguing that a somatic cell from an older human contains mitochondria that's more degraded. Egg cells are all created before birth, and each is pre-seeded with a large number of mitochondria.
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scotty79
1 hour ago
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When the damage accumulates across generations the natural selection has opportunity to weed out particularly harmful instances. You can get a feeling for how important avoiding the mitochondrial damage is and how hard it is to mitigate, by looking at how fiercely the reproductive process protects them from aging.
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emsign
12 minutes ago
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Imagine guys like Musk, Bezos, Zuckerberg or Thiel cloning themselves. That's 100% dystopian. We would never be able to get rid of madmen! Power corrupts and makes the powerful just weird and unable to make rational decisions. That's why people in power need to be replaced regularly to have a stable society.
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b3lvedere
5 minutes ago
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shevy-java
3 hours ago
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A japanese scientist again (Katsuhiko Hayashi is in Osaka).

Shinya Yamanaka created iPSPs in 2009:

https://en.wikipedia.org/wiki/Shinya_Yamanaka

Guess the japanese excel at micromanaging. Although one could say that the research here in the article is more epic than Shinya's discovery, but I remember having watched one of his presentation and it convinced me of pure epicness, if you understand how his team found the "Yamanaka factors". That was by human (work) consistency. About as epic as Christiane Nüsslein-Volhard and her mutant screens, that also involved tons of micro-experiments.

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tsss
6 minutes ago
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We need less people not more.
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Schlagbohrer
1 hour ago
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The origins of stem cells for use in the biosciences and in cosmetics are extremely brutal and should be illegal. Sandra Bullock explains it better than I could: https://youtu.be/PwO3TEj9-5g
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