Autopsy Study Finds Replicating SARS-CoV-2 in the Hearts of Long Covid
78 points
11 hours ago
| 3 comments
| my.uscap.org
| HN
realo
3 minutes ago
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The science is interesting but I must admit I learned a new word today.

A deceased person is also a decedent. Adjective vs noun. Cool.

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nerdsniper
1 hour ago
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I'd be curious to look for any investigation into whether extended paxlovid treatment fixes a significant subset of long COVID.
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thenerdhead
18 minutes ago
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they’ve done 15 days all null and the 25 day one was null but has some unique labs they tested but haven’t posted yet.

Paxlovid does something to antiviral genes and shows there’s something there though in secondary analysis (not posted but has been presented at conferences)

sadly Paxlovid doesn’t actually get rid of the viral pieces remaining and a PROTAC or other therapy might be necessary to degrade the proteins.

https://www.nature.com/articles/s41392-025-02539-7

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internet_user
5 hours ago
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Has this been found in other tissues?
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thenerdhead
4 minutes ago
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strongest evidence so far in gut and immune cells for living organisms.

They did find it in the brain of one patient when doing an unrelated procedure at the NIH. That could be due to many things though. General findings around the CSF/brain have been negative.

Autopsy - https://www.nature.com/articles/s41586-022-05542-y

Long covid - https://www.thelancet.com/journals/laninf/article/PIIS1473-3...

Also this exists in both children and adults.

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npunt
1 hour ago
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Iirc yes. Viral persistence and viral reservoirs are the terms to search for
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